Painful neuropathies.

L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies.

During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-...

Painful diabetic neuropathy pdf

[Botulinum toxin and painful peripheral neuropathies: what should be expected?].

Botulinum toxin type A (BTX-A) is a potent neurotoxin that blocks acetylcholine release from presynaptic nerve terminals by cleaving the SNARE complex. BTX-A has been reported to have analgesic effects independent of its action on muscle tone. The most robust results have been observed in patients with neuropathic pain. Neuropathic pain due to peripheral lesions has been the most widely studied...

Augmenting glial cell-line derived neurotrophic factor signaling to treat painful neuropathies.

Pain in Peripheral Neuropathies Peripheral neuropathies are a group of disorders affecting peripheral nerves, characterized by either distal axonal degeneration or dysfunction of the ensheathing Schwann cells. Depending on the type of peripheral nerve involvement, there are many different symptoms and examination findings in patients with peripheral neuropathy. However, neuropathic pain is prob...

Comparison of sudomotor and sensory nerve testing in painful sensory neuropathies.

OBJECTIVE To compare results of quantitative sudomotor axon reflex testing (QSART), dorsal sural, and sural sensory nerve testing in patients with painful sensory neuropathy (PSN). METHODS Fifty-six patients with symptoms and neurologic examinations consistent with PSN who had both autonomic and nerve conduction studies were identified from 376 patients with a clinical diagnosis of painful ne...